Food and the Gut Microbiota in IBD: A Critical Connection

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Abstract

Purpose of ReviewThe inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the gastrointestinal tract apparently due to an abnormal immune response to environmental factors in genetically susceptible hosts. The composition of the gut microbiome is thought to be a critical environmental factor in IBD, and recent evidence suggests a connection between diet and the intestinal bacteria. In this review, we describe the current evidence regarding the impact of diet on the gut microbiome and how this may be relevant to the pathogenesis of IBD.Recent FindingsNovel culture-independent DNA sequencing technology has revolutionized the approach to the characterization of intestinal bacterial communities. Recent studies have demonstrated an association between the diet and the composition of the human microbiome. Because the development of a “dysbiotic” microbiome is thought to be involved in the pathogenesis of IBD, diet is being investigated as an important etiologic factor.SummaryThe recent studies highlighting the impact of diet on the gut microbiome provide a strong rationale for further investigation of the link between diet, the gut microbiome, and the development of IBD. Such studies may provide novel information about disease pathogenesis as well as identify new therapeutic alternatives for patients suffering from IBD.

Details
Title
Food and the Gut Microbiota in IBD: A Critical Connection
Type of Article
Related Research
Diets studied
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Date
July 1, 2012
Author(s)
Albenberg LG et al
Publication
Current opinion in gastroenterology
Citation

Albenberg, L. G., Lewis, J. D., & Wu, G. D. (2012). Food and the Gut Microbiota in IBD: A Critical Connection. Current Opinion in Gastroenterology, 28(4), 10.1097/MOG.0b013e328354586f. https://doi.org/10.1097/MOG.0b013e328354586f

ISSN Number
0267-1379
Volume
28
Pages
10.1097/MOG.0b013e328354586f

Recent studies have demonstrated an association between the diet and the human microbiome. Because the development of a 'dysbiotic' microbiota is thought to be involved in the pathogenesis of IBD, diet is being investigated as an important etiologic factor.

Somebody in the kitch - view from the back while preparing healthy foods. Cutting board with various healthy foodsPink Milkshake and fruits on a white table and pink backgroundWoman stirring in a pot with vegetables.on the stove

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