Host Sorbitol and Bacterial Sorbitol Utilization Promote Clostridioides difficile Infection in Inflammatory Bowel Disease

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Host Sorbitol and Bacterial Sorbitol Utilization Promote Clostridioides difficile Infection in Inflammatory Bowel Disease

Abstract

Details
Title
Host Sorbitol and Bacterial Sorbitol Utilization Promote Clostridioides difficile Infection in Inflammatory Bowel Disease
Type of Article
Related Research
Diets studied
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Date
March 8, 2023
Author(s)
Yang Z. et al.
Publication
Gastroenterology
Citation

Yang, Z., Qin, J., Zhao, L., Chen, T., Huang, Q., Jian, Y., Zhao, Q., Yang, S., Li, Q., Liu, Q., Otto, M., & Li, M. (2023). Host Sorbitol and Bacterial Sorbitol Utilization Promote Clostridioides difficile Infection in Inflammatory Bowel Disease. Gastroenterology, 164(7), 1189-1201.e13. https://doi.org/10.1053/j.gastro.2023.02.046

ISSN Number
00165085
Volume
164
Pages
1189-1201.e13

Sorbitol and sorbitol utilization in the infecting C difficile strain play major roles for the pathogenesis and epidemiology of CDI in patients with IBD. CDI in patients with IBD may thus be avoided or improved by elimination of dietary sorbitol or suppression of host-derived sorbitol production.

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