The Gut–Brain Axis and Its Role in Controlling Eating Behavior in Intestinal Inflammation
Abstract
Malnutrition represents a major problem in the clinical management of the inflammatory bowel disease (IBD). Presently, our understanding of the cross-link between eating behavior and intestinal inflammation is still in its infancy. Crohn’s disease patients with active disease exhibit strong hedonic desires for food and emotional eating patterns possibly to ameliorate feelings of low mood, anxiety, and depression. Impulsivity traits seen in IBD patients may predispose them to palatable food intake as an immediate reward rather than concerns for future health. The upregulation of enteroendocrine cells (EEC) peptide response to food intake has been described in ileal inflammation, which may lead to alterations in gut–brain signaling with implications for appetite and eating behavior. In summary, a complex interplay of gut peptides, psychological, cognitive factors, disease-related symptoms, and inflammatory burden may ultimately govern eating behavior in intestinal inflammation.
Moran GW, Thapaliya G. The Gut-Brain Axis and Its Role in Controlling Eating Behavior in Intestinal Inflammation. Nutrients. 2021;13(3):981. Published 2021 Mar 18. doi:10.3390/nu13030981
"In summary, a complex interplay of gut peptides, altered gut–brain signaling, cognitive, psychological factors, disease-related symptoms, and inflammatory burden may ultimately guide eating behavior in intestinal inflammation."
"Psychological, cognitive, and behavioral therapeutic interventions may be beneficial to manage disease-related symptoms such as low mood, chronic fatigue, abdominal pain, increased self-monitoring, and impulsivity that may negatively influence eating behaviors."
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